Domestic applications of calcium chloride are as dehumidifiers for closets, cupboards, cars, boats and mobile homes. In many cases, the humidity in these types of enclosed spaces is too high, leading to accelerated micro-biological activity. This growth of mold and bacteria often leads to unwanted odors and may also degrade materials such as textiles, wood, paper and leather. If the air humidity is very high, condensation of water can occur, which can damage many materials and goods by staining or initiating corrosion. By using a calcium chloride dehumidifier, these problems can often be mitigated or completely solved.

In industrial applications, the aim is the same as given above—to reduce humidity in order to protect goods, machinery and electronics. However, the method of application and form of the calcium chloride product is determined by the volume of air needed to be treated. For example, absorption of moisture in transport containers during sea transport requires TETRA's solid calcium chloride as a cost effective and efficient moisture absorbing chemical.